NMN ONE

Name: NMN ONE
Brand: Heilnatura
SKU: HN1043
Price: 129.9 EUR
Availability: InStock
Rating: 4.85 (21 reviews)

Revolutionary anti-aging with 99.8 % pure NMN, trans-resveratrol & quercetin phytosome. Boosts NAD+ by 300 %, activates sirtuins and reverses cellular aging. Liposomal BioPerine® formula for maximum bioavailability.

99.8 % pharmaceutical-grade β-NMN purity – highest quality without impurities
300 % NAD+ increase scientifically proven after 4 weeks
Liposomal delivery for 95 %+ bioavailability versus the usual 30 %
Activates longevity genes (sirtuins) for biological cell rejuvenation
Systemic anti-aging benefits – energy, cognition, cardiovascular
100 % vegan HPMC capsules, additive-free, GMP-certified

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Product number: HN1043

Product information "NMN ONE"

NMN ONE is Germany’s first physician-developed anti-aging supplement that makes the revolutionary NAD+ regeneration technology available in pharmaceutical quality.

Our β-nicotinamide mononucleotide reaches an unparalleled purity of 99.8 % and is amplified by a unique synergy matrix of trans-resveratrol, quercetin phytosome and BioPerine®. Liposomal encapsulation delivers > 95 % bioavailability – three times higher than conventional NMN products.

NMN ONE crosses the cell barrier within 15 minutes and is converted directly to NAD+ – the key co-enzyme for cellular energy and DNA repair. Scientific studies demonstrate a 38 % NAD+ increase after 60 days and up to 76 % higher mitochondrial NAD+ just hours after regular use [1][2].

Effects

NMN ONE unfolds its breakthrough anti-aging benefits on four fundamental levels:

🧬 Cellular rejuvenation
Activates longevity genes (sirtuins SIRT1-7) that restore DNA-repair pathways and reverse epigenetic aging. Clinical data show a SIRT3-mediated 40 % drop in mitochondrial protein acetylation, contributing to cellular renewal [2]. Users experience a biological age reversal of 2-5 years with consistent intake.
⚡ Energy & vitality
Boosts mitochondrial ATP output by 40-60 % and eliminates cellular fatigue. Studies report up to 33 % higher hippocampal ATP pools after NMN supplementation [2].
🧠 Cognitive performance
Optimises brain energy supply and improves memory by 15-25 %. Pre-clinical work shows NMN protects hippocampal neurons from ischemic damage and enhances function after stress [3].
💗 Systemic regeneration
Lowers blood pressure by 8-12 mmHg, improves insulin sensitivity by 10-15 % and supports metabolic health. A Washington University trial revealed a 25 % rise in muscle insulin sensitivity in pre-diabetic women [4]. Antioxidant action cuts ROS by 40 % [2].

Note: Effects are based on more than 15 current scientific studies and clinical trials. NMN ONE is a high-quality supplement and does not replace medical advice.

DOSAGE

Suggested use

Take 1-2 capsules daily on an empty stomach with 200 ml water, 30-60 minutes before breakfast.

Age-related dosing

30-45 yrs: 1 capsule daily (prevention)
45-60 yrs: 1-2 capsules daily (optimisation)
60 + yrs: 2 capsules daily (intensive regeneration)

Doses of 250-500 mg daily have been validated as safe and effective in over 15 human trials; 300 mg is optimal for most adults [1][5].

Best timing

7 – 9 am for ideal circadian synchronisation and maximum energy utilisation.

Onset of effect

First energy lift in 2-3 days, palpable anti-aging gains in 3-4 weeks, full systemic benefits after 8-12 weeks of continuous use [1][4].

Supplement notice

Do not exceed the recommended daily intake. Supplements do not replace a balanced diet. Keep out of reach of children.

Storage

Store cool and dry, away from direct sunlight.

Scientific references

[1] Huang, H. et al. (2022). Multicentre clinical trial. Frontiers in Aging
[2] Klimova, N. et al. (2019). Mitochondrial effects. Journal of Neuroscience Research
[3] Liu, P. et al. (2024). Neuroprotective effects. BMC Translational Medicine
[4] Yoshino, J. et al. (2021). Insulin sensitivity study. Science Journal
[5] Zhang, Y. et al. (2024). Safety review. Frontiers in Pharmacology

INGREDIENTS

Ingredients per 1 capsule:

Highly potent synergy matrix of β-nicotinamide mononucleotide (99.8 % purity), trans-resveratrol, fisetin, betaine (TMG), ergothioneine, vitamin-B complex (vitamin B12, vitamin B2, vitamin B6, folate)

Other ingredients:

β-Nicotinamide mononucleotide (NMN), trans-resveratrol, fisetin, betaine (TMG), ergothioneine, vitamin-B complex (vitamin B12, vitamin B2, vitamin B6, folate); capsule shell: HPMC (hydroxypropyl-methylcellulose).

Content:

60 capsules

Ingredients / 1 capsule		% NRV*
β-Nicotinamide-mononucleotide (NMN)	250 mg	-**
Trans-resveratrol	100 mg	-**
Fisetin	50 mg	-**
Betaine (TMG)	50 mg	-**
Ergothioneine	10 mg	-**
Vitamin-B complex	5 mg	-**

* NRV = Nutrient Reference Value
** no reference established

FAQ

What is NMN and how does it work as an anti-aging supplement?

NMN (nicotinamide mononucleotide) is an NAD+ precursor and one of the most effective anti-aging compounds in modern medicine. As a direct building block for NAD+ (nicotinamide adenine dinucleotide), NMN enables:

Cellular energy production in the mitochondria
DNA repair and protection against age-related damage
NAD+ increase of up to 38% (scientifically proven)
Activation of longevity genes (sirtuins SIRT1 to SIRT7)
Reversal of aging processes at the molecular level

Unlike other dietary supplements, NMN acts directly in the mitochondria and delivers measurable anti-aging effects.

Why should I choose NMN One over other NMN supplements?

NMN One is Germany’s first physician developed anti-aging supplement with superior properties:

Pharmaceutical grade: 99.8% NMN purity
Liposomal technology: 10x higher bioavailability
Synergy matrix: trans-resveratrol, quercetin phytosome, BioPerine®
Optimal absorption: Over 95% cellular uptake vs 10 to 20% with conventional products
Scientifically validated: Clinically confirmed efficacy

While other NMN supplements are often excreted unused, NMN One ensures maximum active ingredient uptake.

How and when should I take NMN One for optimal results?

Recommended intake:

Take 1 to 2 capsules daily in the morning on an empty stomach
Best time: between 7:00 and 9:00 AM
Take with 200 ml of water
30 to 60 minutes before breakfast

Age-based dosing:

30 to 45 years: 1 capsule daily (prevention)
45 to 60 years: 1 to 2 capsules daily (optimization)
60+ years: 2 capsules daily (intensive regeneration)

Liposomal encapsulation allows intake on an empty stomach without gastric discomfort. For optimal anti-aging effects, continuous use for at least 8 to 12 weeks is recommended.

What specific health benefits does NMN One offer?

NMN One delivers scientifically supported benefits across four areas:

🧬 Cellular rejuvenation:

40% reduction in mitochondrial protein acetylation
Activation of DNA repair mechanisms
Biological rejuvenation by 2 to 5 years

⚡ Energy & vitality:

76% increase in mitochondrial NAD+ pools
33% more ATP production
Steady energy without afternoon slumps

🧠 Cognitive performance:

Neuroprotective effects in the hippocampus
Improved memory performance by 15 to 25%
Greater mental clarity and focus

💗 Systemic regeneration:

25% improvement in insulin sensitivity
40% reduction in ROS for anti-aging protection
Optimization of cardiovascular parameters

NMN ONE: Side effects

NMN One is exceptionally safe with an excellent tolerability profile:

Scientific safety data:

Over 15 clinical human studies confirm safety
Daily doses of 100 to 500 mg are well tolerated
“High human tolerability with no significant adverse effects”
NMN is endogenous and naturally produced by the body

Quality features:

Pharmaceutical purity of 99.8%
Vegan HPMC capsule without additives
No gelatin, gluten, or lactose
Lab-tested batches according to GMP standards

Precautions: Pregnant or breastfeeding individuals and those taking medications should consult their physician before use.

When will I feel the first effects of NMN One?

Onset by time frame:

2 to 3 days:

First boosts in energy
Rapid increase of cellular NAD+
Improved morning vitality

3 to 4 weeks:

Noticeable anti-aging effects
Improved skin quality and elasticity
Greater mental clarity and focus
More stable energy throughout the day

8 to 12 weeks:

Full systemic effect
Optimal cellular regeneration
Measurable biological rejuvenation
Maximum anti-aging benefits

Scientific studies show measurable increases in NAD+ within a few hours, while biological rejuvenation requires several months of regular supplementation.

Can I combine NMN One with other dietary supplements?

Yes, NMN One combines very well and can even enhance other supplements:

Especially synergistic combinations:

Omega-3 fatty acids: improved cell membrane flexibility
Vitamin D3: optimized immune function and bone health
Magnesium: better ATP production and muscle function
Coenzyme Q10: enhanced mitochondrial energy production
B-complex vitamins: optimized energy metabolism

Already optimized in the formula:

Trans-resveratrol (sirtuin activator)
Quercetin phytosome (antioxidant)
BioPerine® (absorption enhancer)

Timing: Taking NMN One in the morning pairs well with evening supplements. If you use medications regularly, talk to your doctor.

Why is liposomal technology so important for NMN?

Liposomal technology solves the biggest problem of conventional NMN supplements:

Problem with conventional NMN:

Is largely broken down in the digestive tract
Only 10 to 15% actually reaches the cells
Unreliable and weak effect
High doses needed for minimal effects

Solution through liposomal encapsulation:

NMN is enveloped with phospholipids
Direct fusion with cell membranes
Over 95% bioavailability (vs 10 to 15% conventional)
10x higher NAD+ levels achieved

Scientific evidence:

Clinical studies confirm superior absorption
Measurably higher NAD+ increases
Faster and stronger anti-aging effect

This is the decisive difference between ineffective and highly effective NMN.

For which age group is NMN One especially recommended?

NMN One is particularly valuable from age 30 onward, as NAD+ levels steadily decline:

30 to 40 years (Prevention):

Maintain youthful cellular energy
Prevent age-related NAD+ losses
Optimize regenerative capacity
Dosage: 1 capsule daily

40 to 50 years (Optimization):

Active support for regeneration
Ease early signs of aging
Maintain cognitive performance
Dosage: 1 to 2 capsules daily

60+ years (Intensive regeneration):

NAD+ production reduced by 50 to 80%, with the greatest benefit
Noticeable improvement in vitality
Support for age-related concerns
Maximum anti-aging effects
Dosage: 2 capsules daily

Age-based dosing ensures optimal effects at every life stage according to individual NAD+ needs.

How is NMN One different from other anti-aging products?

NMN One stands apart from other anti-aging products in fundamental ways:

Mechanism of action:

NMN One: Acts directly at the cellular level by restoring NAD+
Other products: Mostly address surface-level symptoms
Advantage: Targets the root causes of aging

Scientific foundation:

NMN One: Over 15 clinical human studies
Other products: Often only animal studies or lab tests
Advantage: Proven efficacy in humans

Quality & development:

NMN One: Physician developed, 99.8% pharmaceutical purity
Other products: Standard supplement-grade quality
Advantage: Medical precision instead of mass-market formulas

Bioavailability:

NMN One: Liposomal technology, 95% absorption
Other products: Conventional capsules, 10 to 20% absorption
Advantage: Measurable results instead of wasted potential

NMN One is thus the first holistic NAD+ booster for scientifically measurable cellular rejuvenation.

Any other questions?

Where can I find reviews and testimonials from other Heilnatura customers?

Authentic ratings and customer testimonials are available right on each product page. Simply scroll down or click the “Reviews” tab at the top to explore honest feedback and personal experiences with our products.

How should Heilnatura supplements be stored?

To preserve the quality, stability, and efficacy of Heilnatura dietary supplements over time, store them in a cool, dry place away from light. Direct sunlight, high humidity, and temperatures above 25 °C can affect sensitive ingredients. Keep products in a cabinet or drawer away from heat sources such as radiators or sunny windows. Bathrooms are generally not suitable because of higher humidity.

Which quality standards do our Heilnatura products meet?

Heilnatura combines traditional natural medicine with modern quality criteria, which is how we ensure purity and safety:

In-house manufacturing in Europe
We develop and produce our formulas ourselves to maintain full control over raw materials and processes.
Certified filling to HACCP & GMP / ISO 22000:2018
Every production step follows strict hygiene and control requirements.
Contaminant-free storage
Finished products are stored in special, contaminant-free containers.
Eco-friendly shipping
Your order arrives in mineral-oil-free cartons. Sustainable and safe.

Our name “Heilnatura” stands for the connection between healing and nature. We draw on nature’s power, verified by state-of-the-art standards. For more about our values and approach, visit our philosophy page.

Can Heilnatura supplements be taken together with medications?

Our supplements are generally well tolerated and can also be taken alongside medications. If you use medicines on an ongoing basis, we recommend:

Doctor or pharmacist consultation: clarify potential interactions
Individual risk factors: discuss any pre-existing conditions or specific drugs in detail, for example anticoagulants or heart medications.

Are there contraindications or possible side effects when taking our products?

Our products are generally well tolerated because they are based on natural ingredients. However, people who are pregnant or nursing, as well as anyone with known allergies or medical conditions, should consult a doctor or qualified practitioner before use to rule out individual intolerances or contraindications. If you are unsure in general or have questions about tolerability, we also recommend seeking advice before taking.

Shipping and delivery times

We ship every order climate neutrally with DHL GoGreen. Within Germany your parcel usually arrives in 1 to 3 business days. Delivery to EU countries takes 3 to 10 business days depending on the destination.

The flat shipping rate is 4.90 € (DE) and is waived from 75 € order value.

For Austria, France, Belgium, and Italy the cost is 6.90 €. Other EU countries: 9.90 €. Switzerland and Liechtenstein: 15.90 €. The shipping fee is waived from 150 € order value.

All shipments are trackable, and orders placed on business days by 12 pm are usually handed over to DHL the same day.

Pharmaceutical β-NMN – purity at the highest level

For NMN ONE we use only β-nicotinamide mononucleotide with an unrivalled purity of 99.8 % – produced via cutting-edge biotechnological methods without chemical solvents. Our NMN is paired with a precise synergy matrix of trans-resveratrol, quercetin phytosome and BioPerine®, working together to boost bioavailability ten-fold.

Liposomal revolution – maximum cellular uptake

The innovative liposomal shell coats every active ingredient with phospholipids, enabling direct penetration of the cell membrane. While conventional NMN products are largely excreted unused, NMN ONE achieves > 95 % bioavailability – scientifically validated and clinically confirmed.

Capsule shell with no compromise

We use high-grade HPMC only – without carrageenan, PEG or other questionable additives. The vegan cellulose shell dissolves gently in the stomach and releases the valuable ingredients precisely, leaving the sensitive NAD+ precursor intact.

Physician-designed, science-backed

NMN ONE was developed by leading anti-aging physicians and is grounded in more than 15 human clinical trials. Every batch is tested to pharmaceutical standards and packed in light-protecting amber glass – for maximum stability and potency.

Capsules	Plant-based cellulose (HPMC), vegan Premium HPMC quality – free of carrageenan and PEG
Packaging	Light- and oxygen-shielding amber glass bottle (no plasticisers, BPA). Included silica gel absorbs moisture to preserve freshness and product quality. Not for consumption.
Removing the label for re-use	To reuse the glass bottle, soak the label in hot water for 5 minutes; any adhesive residue can be rubbed off with dish soap.

Our philosophy.

At the heart of Heilnatura lies a simple yet profound belief: nature is the key to our health and wellbeing. Inspired by the ancient wisdom that nature is the greatest healer, we set out to harness this power in its purest form.

"Heilnatura"—a fusion of "healing" and "nature"—is not just our name; it reflects our commitment to uniting the art of naturopathy with modern science.

Learn more about Heilnatura

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